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Manufacturing and processing of organic chemical devices, application technology
  • The present invention relates to new compounds and new complexes of these compounds and metals. The novel compounds and complexes of the present invention can be used in the diagnosis and treatment of diseases. Metal complexes, such as those containing radioactive metals, are finding increasing use as diagnostic and therapeutic agents. Of particular interest are those complexes that contain a biologically active moiety that can be selectively absorbed by a desired site to facilitate the evaluation and treatment of a subject. this...
  • The present invention relates to a method for producing a taxane-type diterpene including paclitaxel, which is a good agent for treating ovarian cancer, breast cancer, lung cancer, and the like. Paclitaxel, used for the treatment of ovarian cancer, breast cancer, lung cancer, etc., is a taxane-type diterpene that is identified after being isolated from Taxus brevifolia NUTT. Taxus is a taxus belonging to the taxus Family plants, paclitaxel has a complex ester group related to the above pharmacological activity. can...
  • The present invention relates to a method for producing a hydroxyalkanal by hydrating an unsaturated aldehyde in an aqueous solution in the presence of a catalyst. Conventionally, as a method for producing 3-hydroxypropionaldehyde, which is one of the hydroxyalkanals, acrolein which is one of the unsaturated aldehydes is hydrated in an aqueous solution in the presence of a catalyst, there are various production methods described below. That is, USP 2,434,110 discloses a method of using an inorganic acid such as sulfuric acid as the acidic homogeneous catalyst in the reaction system. But this method ...
  • The present invention relates to a method for preparing benzophenone imines from benzophenone in liquid ammonia. In the direct reaction of benzophenone in molten form or in solution with gaseous or liquid ammonia, iron (III) chloride (JP-A-61 / 030563, yield 57%), organic acid must be added as a catalyst, Such as benzoic acid (US-A-4130586, yield 18-65%) or ammonium chloride (SyntheticCommunica ...
  • The present invention relates to piperazine derivatives, tautomers and stereoisomers of the following general formula, including mixtures and salts thereof, especially salts with pharmaceutically acceptable acids or bases, which have effective pharmacological properties, In particular, the effect of inhibiting the aggregation effect, the present invention also relates to a pharmaceutical composition containing these compounds and uses thereof, and a preparation method thereof. The prerequisite in the above general formula I is that if Ra represents 4-pyridyl, it is impossible to (a) Y1 simultaneously ...
  • The present invention relates to an optically active benzothiaheptin derivative having osteogenesis promoting activity, bone resorption inhibiting activity, and other activities, and a medicament for preventing or treating bone diseases containing the same as an active ingredient. Bone disease is a pathological condition or disease that involves certain symptoms or tendencies caused by a decrease in bone mass beyond a certain level. The main symptoms of osteoporosis (a bone disease) are kyphosis, and the lower back, vertebrae, femoral neck, lower radius, ribs, upper humerus ...
  • The invention relates to a new method for separating and separating (meth) acrylic acid from a mixture containing (meth) acrylic acid and an inert hydrophobic organic liquid having a boiling point higher than (meth) acrylic acid as a main component and also containing a lower aldehyde as a minor component . (Meth) acrylic acid is abbreviated and means acrylic acid or methacrylic acid. (Meth) acrylic acid itself or its various forms of esters are of great importance for the preparation of polymers such as adhesives. (Methacrylate...
  • The present invention relates to a method for preparing acrylic acid. In particular, the present invention relates to a molybdenum / vanadium-based oxide catalyst prepared under specific conditions, using molecular oxygen or a gas containing molecular oxygen to catalyze the oxidation of acrolein or Acrylaldehyde gas to make acrylic acid. A number of improved catalysts have been proposed for the efficient preparation of acrylic acid by gas-phase catalytic oxidation of acrolein. Most of these are molybdenum / vanadium-based catalysts containing molybdenum and vanadium as the main components ...
  • The present invention relates to a new catalyst for the preparation of methacrylic acid by gas-phase oxidation of methacrylaldehyde, which is obtained through the gas-phase catalytic oxidation of methacrylic acid or tert-butanol. It has been reported that a variety of catalysts can be used as catalysts for the gas-phase oxidation of methacrylic acid to prepare methacrylic acid, and heteropoly acid derivatives have been reported as catalysts for the preparation of methacrylic acid in many patent publications. However, due to the nature of catalysts including heteropoly acid derivatives, they have some ...
  • The invention belongs to a method for preparing dimethyl ether from synthesis gas in one step, in particular to a catalyst used and a preparation process thereof. Dimethyl ether is not only the main intermediate for the improvement of gasoline conversion from synthesis gas to methanol, but also an important raw material for the production of a variety of chemical products, and has many unique uses in the pharmaceutical, dye, and pesticide industries. Dimethyl ether may also gain increasing attention as a substitute for city gas or liquefied gas or even diesel. One-step production of Dijiao from syngas ...
  • The present invention relates to a method for directly preparing an alkyl halodifluoroacetate by the reaction of 1,1-difluorotetrahaloethane with an alcohol. Alkyl difluoroacetate is an intermediate in the synthesis of pharmaceuticals and plant health products. Many methods for obtaining these alkyl halodifluoroacetates have been described. The most commonly used of these methods is the reaction of an alcohol with a halodifluoroacetic acid, or preferably the corresponding fluoride and chloride. These halogenated ...
  • The present invention relates to the synthesis of alkanesulfonic acids. Specifically, the content of the present invention is to prepare C1-C4 alkanesulfonic acids from corresponding sulfur-containing derivatives. Paraffinic acids and their salts have many industrial applications, such as detergents, emulsifiers, esterification catalysts, and hardeners for certain resins. Industrially, alkanesulfonic acids are often produced from alkane through sulfonation or chlorosulfonation. However, the disadvantage of these two synthetic methods is that it leads to the formation of sulfonation on different carbon atoms of the hydrocarbon chain ...
  • The present invention relates to new 1-cyclopropyltetrazolinones, their preparation methods, their use as herbicides, new intermediates in their preparation processes, and their preparation methods. Certain substituted tetrazolinones are known to have herbicidal activity [see US Patent 4,618,365 (= EP-A-146,279); 4,826,529; 4,830,661; 4,956,469; 5,003,075; 5,01 ...
  • The present invention relates to a method which comprises dinitrolating 1,3-dichlorobenzene to obtain a mixture of 1,3′-dichloro-4,6 / 2,4-dinitrobenzene, followed by sodium benzyl alcohol. (Sodiumbenzylate) reaction to obtain 1,3-dibenzyloxy-4,6-dinitrobenzene and catalytic hydrogenation. 4,6-Diaminoresorcinol is an important monomer structural unit of plastics, especially an important monomer constituting polybenzoxazole (high molecular, 19 ...
  • The present invention relates to a 1-oxo-2- (benzenesulfonylamino) pentylpiperidine derivative, a preparation method thereof, and a medicament thereof. The compound of the present invention is represented by the following formula (I): wherein R1 is hydrogen or (C1-C4) alkyl, R2 is hydrogen or straight or branched (C1-C4) alkyl, and R3 is straight or branched (C1- C7) alkyl,-(CH2) nOCH3 group (where n is 1, 2 or 3) or -CH2O (C2H4O) mCH3 (...
  • The present invention relates to a method for stereo-controlled synthesis of D-amino acids. The following formula (1) represents a D-amino acid-N- (S) -α-alkylbenzylamide in which R1 is methyl, ethyl, or isopropyl, and R2 is methyl or ethyl. They can be used as intermediates for substances with strong sweetness, as described in US Pat. No. 5,286,509. The formula (1) has a D-amino acid structure as the carbon atom marked with * in the following formula, and R1 has 1 to ...
  • The invention relates to a reaction of organic primary amine and phosgene in an organic solvent at a temperature of 60-100 ° C, wherein the reaction mixture is circulated through a bubble column. A method for continuously preparing an organic isocyanate by reacting an organic primary amine with phosgene in an organic solvent has been introduced in many places and has been produced on a large scale (for example, see UllmannsEnzyklopdiederTechnischenChem ...
  • The present invention relates to 11β-aryl-4-estren of general formula I and a suitable acid addition salt thereof, and a method for preparing the same, a pharmaceutical composition containing the compound, an application in preparing a medicament, and the purpose thereof. New intermediate product required, where X represents oxygen atom, oxime group N-OH or 2 hydrogen atoms, R1 represents hydrogen atom or methyl group, R2 represents hydroxyl group, C1-C10-alkoxy- or C1-C10 Acyloxy, R3 represents a hydrogen atom, ...
  • The present invention relates to a new method for preparing β-keto alcohol from an aldehyde through a specific condensation reaction and some new products made by this method. Chemistry Letters 1991, 1377-1378 (Inoue et al.) Discloses cyclic α-methylidene carbonate, which is 4,4-dimethyl-5-methylidene-1,3-dioxolane-2-one (hereinafter ("Cyclic carbonate") and the cyclization reaction between aromatic aldehydes, cracking off dioxin ...
  • The present invention relates to a novel method that can be used to convert amino acids into halomethylketones and then into amino acid epoxides. Such epoxides are important intermediates for the synthesis of inhibitors of renin and HIV protease. The inhibitors of renin and HIV protease are particularly useful for treating and / or preventing HIV infection (AIDS). The amino acid alpha-halomethyl ketone can be used as an irreversible active site inhibitor of certain cysteine and serine-containing proteases ...
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